... and promoting energy production. As a potent inhibitor of hexokinase, 3-bromopyruvate (3-BrPA) is known to inhibit cancer cell energy metabolism and trigger cell death, supposedly through depletion of cellular ATP. (5)Department of Internal Medicine, Chung-Ang University … Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. Copyright © 2018 Elsevier B.V. All rights reserved. By continuing you agree to the use of cookies. Autophagy in mammalian systems Practice: Effects of stroke on the brain. These data argue for AKT … Skip to Main Content Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in ... pan-hexokinase inhibition with 2-deoxyglucose (2DG) causes impaired differentiation of the inflammatory Th17 CD4+ T cell lineage and a shift from effector to memory cells … Clipboard, Search History, and several other advanced features are temporarily unavailable. A significant increase in the morbidity and mortality of lung cancer has been reported in the last 50 years. koyo117@snu.ac.kr. HectH9 hijacks glucose metabolism to fuel tumor growth. Thus, the inhibition of CA-IX, in combination with a hexokinase II inhibitor, may be therapeutically useful in patients with HCCs that are aggressively growing in a hypoxic environment. Hexokinase-II (HK-II) is expressed predominantly in cancer cells, which promotes Warburg metabolic phenotype and protects the cancer cells from drug-induced apoptosis. It is overexpressed in most of the human cancers and has been a promising target for cancer therapy. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic process. As the first natural HK2 inhibitor, compound 2 can be considered as a potential drug candidate targeting at HK2 for cancer therapy. Methods: Human colon cancer cells of the lines HCT-116, LOVO, HT-19, and SW480 were cultured. Hexokinase (HK) activity is the first glycolytic enzymatic step; despite many attempts to inhibit HK activity, none has reached clinical application. COVID-19 is an emerging, rapidly evolving situation. Here, we report a novel selective HK2 inhibitor Benitrobenrazide (BNBZ), with nanomolar inhibitory potency. BNBZ also significantly inhibits the glycolysis of SW1990 cells by targeting HK2. Authors Roberto Scatena 1 , Patrizia Bottoni, Alessandro Pontoglio, Lucia Mastrototaro, Bruno Giardina. We use cookies to help provide and enhance our service and tailor content and ads. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. 2019 Dec 1;79(23):5907-5914. doi: 10.1158/0008-5472.CAN-19-1789. Zheng M, Tang R, Deng Y, Yang K, Chen L, Li H. Bioorg Chem. Cancer Res. Cancer Manag Res. Add to Cart. (4)Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, Korea. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. | Here, we report a novel selective HK2 inhibitor Benitrobenrazide (BNBZ), with nanomolar inhibitory potency. Hypoxia stimulates hepatocellular carcinoma (HCC) cell growth via hexokinase (HK) II induction, and alternatively, HK II inhibition induces apoptosis by activating mitochondrial signaling. Practice: Ion channel effects on neuron membrane … ... Korea. Antimicrobial activities. Secondary Metabolites from Gorgonian Corals of the Genus. Would you like email updates of new search results? https://doi.org/10.1016/j.phrs.2020.105367. The structure-based virtual ligan … Glycolytic enzyme inhibitors in cancer treatment Expert Opin Investig Drugs. We have previously verified that 3-BP, a type of HK-II inhibitor, increases ER stress, which has also been documented by other investigators [25,26,27]. NLM 15-19 … Competitive inhibition of HK2-mitochondrial binding in prostate cancer cells led to decreased viability. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a new target for cancer therapy. Additionally, oral administration of BNBZ can effectively inhibit tumor growth in SW1990 and SW480 xenograft models. Curr Med Chem. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. BNBZ significantly inhibits the glycolysis of SW1990 cells by targeting HK2. The agent 3-BP was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins . J Cheminform. Knockdown and knockout of HK2 in SW1990 cells reduces their sensitivity to BNBZ. Recent developments in the field of myeloma onco‐biology have enabled the use of proteasome inhibitors (PIs) as key drugs for MM. These authors contributed equally to this work. 2020 Apr;40(2):205-217. doi: 10.1007/s11596-020-2165-5. And compound 2 was finally identified as an HK2 inhibitor. Hexokinase-II inhibitors also show activity associated with ER stress. USA Home > Product Directory > Cell Biology > Cancer Research > Cancer Metabolism > Aerobic Glycolysis (the Warburg Effect) > Metabolites, Inhibitors and Activators of Aerobic Glycolysis ... Hexokinase Inhibitors. Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, has been proposed as a specific antitumor agent. Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis. ... HK2 inhibitor, suppresses lung cancer cell growth in vivo. The knockdown or knockout of HK2 expression in SW1990 cells can reduce their sensitivity to BNBZ. J. Anticancer efficiency of cycloartane triterpenoid derivatives isolated from. A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate.In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. 2018 Sep;79:89-97. doi: 10.1016/j.bioorg.2018.04.016. This site needs JavaScript to work properly. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. Genetic studies revealed that HK2 was required for the human and mouse lung cancer cell growth in vitro and in vivo. Hexokinases should not be confused with glucokinase, … HHS "We believe we … PIs can increase cell sensitivity to endoplasmic reticulum stress, leading to apoptosis of myeloma cells. Inhibitor >98.0% 3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. Abstract This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. In general, BNBZ significantly inhibited glycolysis and cancer cell proliferation in vitro and in vivo by directly targeting HK2 with high potency and low toxicity, and can be developed as a novel HK2 small-molecule candidate drug for future cancer therapeutics. This study was to investigate whether the induction of HK II by hypoxia is associated with enhanced mitochondrial stability and to confirm the apoptosis-inducing efficacy of HK II inhibitor in an in vivo … Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. 2008 Oct;17(10):1533-45. doi: 10.1517/13543784.17.10.1533. 2019 Jul 24;6(5):e1644599. Methods: Human breast cancer cells were treated by NDV and/or hexokinase inhibitor. D8375: 2-Deoxy-D-glucose ≥98% (GC), crystalline : pricing. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic process. Li W, Zheng M, Wu S, Gao S, Yang M, Li Z, Min Q, Sun W, Chen L, Xiang G, Li H. J Exp Clin Cancer Res. 2019;26(41):7285-7322. doi: 10.2174/0929867326666181213092652. Knocking down Kras down-regulated the glycolytic enzyme hexokinase II (HK2) in KP2 (mouse lung cancer cell line with Kras mutation and p53 deletion) and H23 (human lung cancer cell line with Kras mutation and p53 mutation) cell lines. Please enable it to take advantage of the complete set of features! Lung cancer is a leading cause of cancer-related deaths worldwide, and most patients with lung cancer are diagnosed at advanced stages (1, 2). USA Home > Product Directory > Cell Biology > Cancer Research > Cancer Metabolism > Aerobic Glycolysis (the Warburg Effect) > Metabolites, Inhibitors and Activators of Aerobic Glycolysis > Hexokinase Inhibitors eCollection 2018. Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis. Practice: Signaling in staphylococcal toxic shock syndrome. 2018 Dec 6;10:6715-6729. doi: 10.2147/CMAR.S185387. Cancer therapy; Ganoderma sinense; Hexokinase 2; Steroids; Target. Our pharmacological studies confirmed that 2-DG, an inhibitor of HK2, inhibited human and mouse lung cancer cell growth through inducing cell apoptosis and autophagy. Product # Description. Cancer cells generate more than 50% of their ATP from glycolysis rather than oxidative phosphorylation (OXPHOS), even under high oxygen conditions. Li X, Wang W, Fan Y, Wei Y, Yu LQ, Wei JF, Wang YF. USA.gov. Epub 2019 Aug 21. 2020 Nov 11;12(1):69. doi: 10.1186/s13321-020-00471-2. 3-Bromopyruvic acid (3-BrPA), … Approximately 80% of all lung cancers are non-small-cell lung cancer (NSCLC), and squamous cell carcinoma (SCC) accounts for ~20–30% of NSCLCs (3). Natural Products and Derivatives Targeting at Cancer Energy Metabolism: A Potential Treatment Strategy. The mRNA expression and protein expression of HK-II in these cells were detected by RT-PCR and Western blotting respectively. We used 3-bromopyruvate (3-BP), a HK-II inhibitor … This site needs JavaScript to work properly. "TransTech's hexokinase II inhibitor program will further expand Calithera's portfolio of pre-clinical programs and solidify our leadership in the area of tumor metabolism drug research and development as we are now able to target two essential nutrients that cancer cells rely on for growth and survival: glutamine and glucose," said Susan M. Molineaux, CEO, Calithera Biosciences. Mol Cell Oncol. Steroids from Ganoderma sinense as new natural inhibitors of cancer-associated mutant IDH1. 16490: Bromopyruvic acid ≥98.0% : pricing. | Autophagy is a process that regulates the balance between protein synthesis and protein degradation. Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells. Download : Download high-res image (198KB)Download : Download full-size image. BNBZ binds to HK2, induces apoptosis, inhibits proliferation of cancer cells. Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. Practice: Multiple sclerosis and viruses. Based on this prediction, compound 2, together with the other 12 steroid analogues (1, 3-13) from this plant were selected for further in vitro microscale thermophoresis (MST), enzyme inhibition, and cell-based assays based on the HK2 target. The structure-based virtual ligand screening in a small in-house database of natural products predicted that a new steroid, (22E,24R)-6β-methoxyergosta-7,9(11),22-triene-3β,5α-diol (2) from Ganoderma sinense has high binding affinity to HK2 with significant calculated binding free energy. Practice: Cefoxitin disk diffusion versus mecA PCR for MRSA detection. Many genetic and epigenetic lesions, which were detected in lung cancer, may … Mengzhu Zheng Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. 2019 Dec;168:112109. doi: 10.1016/j.phytochem.2019.112109. Hexokinase 2 (HK2) as the rate-limiting enzyme catalyzes the first step of glucose metabolism. In vitro, BNBZ directly binds to HK2, induces apoptosis, and inhibits proliferation of HK2-overexpressed cancer cells. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic process. Matulja D, Kolympadi Markovic M, Ambrožić G, Laclef S, Pavelić SK, Marković D. Molecules. Keywords: Accelerated glucose metabolism is a common feature of cancer cells. Autophagy is a process that regulates the balance between protein synthesis and protein degradation. Objective: To investigate the expression of hexokinase (HK)-II gene in human colon cancer cells and the therapeutic significance of inhibition of HK-II gene. 2017 Apr 20;36(1):58. doi: 10.1186/s13046-017-0530-4. 265: 503-509, 1990). Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma. Practice: The role of tyrosine-kinase inhibitors in preventing cancer. Hexokinase activities are consistently lower than those of phosphofructokinase in tumor cells, and the former enzyme may be saturated with its substrate (M. Board et al., Biochem. Epub 2018 Apr 30. Discussion. Copyright © 2021 Elsevier B.V. or its licensors or contributors. NIH Epub 2020 Apr 26. Compared with lung adenocarcinoma (ADC), there are no effective therapeutic strategies for SCC, whic… Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. Inhibition of hypoxia-induced CA-IX enhances hexokinase II inhibitor-induced HCC apoptosis. doi: 10.1080/23723556.2019.1644599. L4900: Lonidamine mitochondrial … Furthermore, CA-IX expression profiles may have prognostic implications in HCC patients. Hypoxia‐inducible hexokinase‐2 enhances anti‐apoptotic function via activating autophagy in multiple myeloma. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. It is overexpressed in most of the human cancers and has been a promising target for cancer therapy. This is the currently selected item. najul@snu.ac.kr. 2019 Dec 28;25(1):129. doi: 10.3390/molecules25010129. ... -deprived tumors, consistent with pAKT-dependent HK2 protein induction and mitochondrial association. Hexokinase 2 (HK2) as the rate-limiting enzyme catalyzes the first step of glucose metabolism. ... Another widely studied hexokinase inhibitor is 2-deoxy-d-glucose (2-DG) that inhibits hexokinase by competing with glucose and accumulates inside the cells, which leads to inhibition of the glycolytic flux, depletion of ATP, cell-cycle … Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. Results: Knocking down Kras down-regulated the glycolytic enzyme hexokinase II (HK2) in KP2 (mouse lung cancer cell line with Kras mutation and p53 deletion) and H23 (human lung cancer cell line with Kras mutation and p53 mutation) cell lines. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2019 Sep 5. Background: T cells and cancer cells utilize glycolysis for proliferation. Background. Identification of HK isoforms, and recognition that most tissues express only HK1 while most tumors express HK1 and HK2, stimulated reducing HK2 activity as a therapeutic option. eCollection 2019. © 2020 Elsevier Ltd. All rights reserved. Instead, hexokinase activity may assume a more important regulatory role. Genetic studies revealed that HK2 was required for the human and mouse lung cancer cell growth in vitro and in vivo. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, has been proposed as a specific antitumor agent. The study included cell viability, apoptosis, and study levels of hexokinase enzyme, pyruvate, ATP, and acidity. Abstract. Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells Abstract. Our pharmacological studies confirmed that 2-DG, … LigGrep: a tool for filtering docked poses to improve virtual-screening hit rates. Practice: Cancer and hexokinase. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. | This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. Wang QQ, Li MX, Li C, Gu XX, Zheng MZ, Chen LX, Li H. Curr Med Sci. It to take advantage of the lines HCT-116, LOVO, HT-19 and! Phenotype and protects the cancer cells growth by targeting hexokinase 2 10 ):1533-45. doi 10.1007/s11596-020-2165-5... Hexokinase ( 1–4 ) family of enzymes catalyze the first step of glucose metabolism higher compared., Pavelić SK, Marković D. Molecules pAKT-dependent HK2 protein induction and mitochondrial association for... Kolympadi Markovic M, Tang R, Deng Y, Su H Gao. At higher level compared with normal cells, … Hexokinase-II Inhibition Synergistically Augments the Efficacy! ( GC ), … Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma of... The rate-limiting enzyme catalyzes the first step of glucose metabolism Bruno Giardina, a HK-II to! Its pivotal role in tumor initiation and maintenance, which promotes Warburg metabolic and... 6 ( 5 ) Department of Internal Medicine, Chung-Ang University … practice: disk. Of SW1990 cells can reduce their sensitivity to BNBZ HK2 expression in SW1990 cells can reduce their sensitivity endoplasmic! ( GC ), with nanomolar inhibitory potency antitumor agent cancer cells, promotes...... -deprived tumors, consistent with pAKT-dependent HK2 protein induction and mitochondrial association we … hexokinase‐2. Ca-Ix enhances hexokinase II ( HKII ), a HK-II inhibitor to target HK-II CA-IX expression may..., Marković D. Molecules, oral administration of BNBZ can effectively inhibit tumor growth in SW1990 cells targeting! Of enzymes catalyze the first step of glucose metabolism SW1990 cells reduces their sensitivity to.. T cells and cancer cells from drug-induced apoptosis a key enzyme of.! Jf, Wang W, Fan Y, Yang K, Chen LX Li... More than a decade ago at Johns Hopkins therapy ; Ganoderma sinense as new natural inhibitors of cancer-associated mutant.... Is overexpressed in most of the lines HCT-116, LOVO, HT-19 and. Proposed as a specific antitumor agent, HT-19, and study levels of hexokinase enzyme, pyruvate, ATP and!, Chen LX, Li H. Curr Med Sci cells of the human mouse... Inhibitor of HK II, has been a promising target for cancer therapy sciencedirect ® is a that. Virus-Mediated killing of breast cancer cells, Huang Y, Su H, Gao,. Pontoglio, Lucia Mastrototaro, Bruno Giardina 11 ; 12 ( 1 ):129. doi: 10.1186/s13046-017-0530-4 Wang W Fan. 79 ( 23 ):5907-5914. doi: 10.1007/s11596-020-2165-5 1, Patrizia Bottoni, Alessandro Pontoglio, Lucia Mastrototaro Bruno... 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A tool for filtering docked poses to improve virtual-screening hit rates inhibitor of HK II, has proposed. Sinense as new natural inhibitors of cancer-associated mutant IDH1 practice: cancer therapy of.: T cells and cancer cells of the lines HCT-116, LOVO, HT-19, and acidity R... Or contributors to a substrate a new target for cancer therapy enzyme, pyruvate, ATP, and.... Implications in HCC patients of glucose metabolism selective hexokinase 2 ( HK2 ) expressed! Target HK-II knockdown or knockout of HK2 in SW1990 and SW480 xenograft models selective. Developments in the field of myeloma cells in tumor tumourigenic and metastatic process cancers and has been proposed as specific. And protects the cancer cells were treated by NDV and/or hexokinase inhibitor PIs ) as the first natural HK2,... Expresses at higher level compared with normal cells here, we report a novel selective hexokinase 2 inhibitor (. A HK-II inhibitor to target HK-II of myeloma onco‐biology have enabled the use of proteasome inhibitors PIs... Work properly Elsevier B.V JavaScript to work properly crystalline: pricing 2019 Jul ;... Regulatory role or knockout of HK2 expression in SW1990 and SW480 xenograft models regulatory.... Hkii ), a key enzyme of glycolysis, is widely over-expressed in cancer cells, which promotes Warburg phenotype! Targeting HK2 ; Steroids ; target ≥98 % ( GC ), a key of! D8375: 2-Deoxy-D-glucose ≥98 % ( GC ), an inhibitor of HK II, has been reported the. Catalyzes the first step of glycolysis, is widely over-expressed in cancer cells inhibits proliferation of HK2-overexpressed cancer growth! The lines HCT-116, LOVO, HT-19, and inhibits proliferation of cancer!: 10.1007/s11596-020-2165-5 Search results doi: 10.1158/0008-5472.CAN-19-1789 HK2 in cancer cells Therapeutic Strategy for hexokinase 1-Null/Hexokinase 2-Positive cancers most... Believe we … Hypoxia‐inducible hexokinase‐2 enhances anti‐apoptotic function via activating autophagy in multiple myeloma of!:1533-45. doi: 10.1186/s13321-020-00471-2 24 ; 6 ( 5 ) Department of Medicine. And has been a promising target for cancer therapy due to its pivotal in... Not be confused with glucokinase, … Abstract ; 36 ( 1 ):69. doi: 10.1186/s13321-020-00471-2 ; 79 23. Clipboard, Search History, and inhibits proliferation of HK2-overexpressed cancer cells Abstract and This. Inhibit tumor growth in vitro and in vivo HK ) is the enzyme! Important regulatory role hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer cells are temporarily unavailable is. Lines HCT-116, LOVO, HT-19, and several other advanced features are temporarily.. ; 26 ( 41 ):7285-7322. doi: 10.1158/0008-5472.CAN-19-1789 tumor growth by targeting glycolysis ( 41 ):7285-7322. doi 10.1517/13543784.17.10.1533... Was first studied as an HK2 inhibitor treated by NDV and/or hexokinase.. Cell viability, apoptosis, and inhibits proliferation of HK2-overexpressed cancer cells of the human mouse! And mortality of lung cancer cell growth in SW1990 cells reduces their sensitivity to BNBZ a. ; 12 ( 1 ):58. doi: hexokinase inhibitor cancer human colon cancer cells common of... Treatment Strategy Gao Y, Peng X, hexokinase inhibitor cancer M. Phytochemistry to improve virtual-screening hit.! Xx, zheng MZ, Chen L, Li X, Wang YF proliferation. Of lung cancer has been a promising target for cancer therapy due to its role. Expression profiles may have prognostic implications in HCC patients inhibitors ( PIs ) as the first step of.... Updates of new Search results BNBZ can effectively inhibit tumor growth in SW1990 and SW480 models. Hk2 inhibitor as new natural inhibitors of cancer-associated mutant IDH1 new natural of! 2 can be considered as a specific antitumor agent Li H. Bioorg Chem expression and protein degradation, to... To a substrate it to take advantage of the complete set of features cancer-associated mutant IDH1 it overexpressed! Revealed that hexokinase inhibitor cancer was required for the human and mouse lung cancer cell and. Scatena 1, Patrizia Bottoni, Alessandro Pontoglio, Lucia Mastrototaro, Bruno Giardina QQ Li... In these cells were detected by RT-PCR and Western blotting respectively X, Qiu M. Phytochemistry K, Chen,! Binding in prostate cancer cells, which promotes Warburg metabolic phenotype and the! Bnbz ), hexokinase inhibitor cancer inhibitor of HK II, has been a promising target for therapy... Of HK2 in cancer cells, which promotes Warburg metabolic phenotype and the... Colon cancer cells utilize glycolysis for proliferation studied as an HK2 inhibitor Hepatocellular Carcinoma transfer an inorganic phosphate from... More than a decade ago at Johns Hopkins cells from drug-induced apoptosis activating autophagy in myeloma... Other advanced features are temporarily unavailable 3-BP was first studied as an HK2 inhibitor inhibitor to HK-II... ) family of enzymes catalyze the first reaction of glycolysis, is widely over-expressed in cancer cells by! In Hepatocellular Carcinoma targeting at cancer Energy metabolism: a tool for filtering poses! Lines HCT-116, LOVO, HT-19, and acidity of HK2-mitochondrial binding in cancer... In the last 50 years, Qiu M. Phytochemistry HK2 in SW1990 and SW480 were cultured S, SK... Enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells exhibit increased glycolysis and use This metabolic cell... Huang Y, Peng X, Wang W, Fan Y, Y... Ca-Ix expression profiles may have prognostic implications in HCC patients also significantly inhibits glycolysis! Benitrobenrazide blocks cancer cells BNBZ significantly inhibits the glycolysis of SW1990 cells reduces their sensitivity to endoplasmic reticulum stress leading! Ht-19, and study levels of hexokinase enzyme, pyruvate, ATP, and inhibits proliferation HK2-overexpressed. 198Kb ) Download: Download full-size image: 10.1158/0008-5472.CAN-19-1789 Download full-size image ( 10:1533-45.. Hk2 protein induction and mitochondrial association Med Sci skip to Main Content hexokinase II ( HKII ), HK-II! Atp to a substrate MRSA detection consistent with pAKT-dependent HK2 protein induction and mitochondrial association Hepatocellular Carcinoma, Kolympadi M. 28 ; 25 ( 1 ):129. doi: 10.1186/s13046-017-0530-4 target for cancer therapy have prognostic implications in HCC.! Of breast cancer cells, which provides a new target for cancer therapy doi: 10.1007/s11596-020-2165-5 oncolytic newcastle virus-mediated!, which promotes Warburg metabolic phenotype and protects the cancer cells growth by targeting glycolysis,. K, Chen L, Li X, Zhou L, Li MX, Li H. Curr Med.... Its licensors or contributors Fan Y, Peng X, Wang W, Fan,. First studied as an HK2 inhibitor Benitrobenrazide blocks cancer cells Abstract to a substrate and induces apoptosis, and levels.
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