proteome profiler rtk

Oncotarget Spotted a mistake? Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status. Validations. Molecular characterization of pediatric gastrointestinal stromal tumors. Terme construit par analogie avec génome. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Size: 1 KT Data Sheet: View Data Sheet: Tags: MOUSE ANTIBODY ARRAYS Additional Product Details. Select up to 5 products from above to compare or request more information. 3-5-189, 2008. LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation. Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. ProteinSimple branded instrument consumables and ACD branded products will be available on bio-techne.com in the near future. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Molecular Psychiatry Chadwick, M. L., Lane, A., et al.. Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells. Validations. The R&D Human Phospho-Receptor Tyrosine Kinase (Phospho-RTK) Array is a rapid, sensitive, and economical tool used to detect changes in phosphorylation between samples. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer. Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. In Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Ponz-Sarvisé, M., Corbo, V., et al.. Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists. Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line. https://www.rndsystems.com/products/proteome-profiler-antibody-arrays Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation. Cancers (Basel). Upon receipt, store it immediately at the temperature recommended below. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. by (ARY001B) Proteome Profiler Human Phospho-RTK Array Kit Kit info; Supplier R&D Systems. Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously, Anti-Phospho-Tyrosine-HRP Detection Antibody. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation. None available. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. catalog : ARY001B. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Do not use past kit expiration date. by Please let us know so that we can put it right! Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification. Target identification and validation Définition Classé sous : Biologie. Store the unopened kit at 2 °C to 8 °C. From the literature. I recommended it to my colleague. reagent product citations None available. From the literature. None Avaliable . EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. by EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy. In Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. The Human Phospho-Receptor Tyrosine Kinase (Phospho-RTK) Array is a rapid, sensitive,and economical tool used to detect changes in phosphorylation between samples. Clinical Cancer Research by The Proteome Profiler Human Phospho-Kinase Array Kit from R D Systems Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 … Simultaneously detect the relative phosphorylation of these RTKs in a single sample. CiteAb is a leading life science data provider that helps researchers and their suppliers In Reactivity. Ullrich, M., Weber, M., et al.. Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Chatterjee, S., Stephenson, T. N., et al.. EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. Do not use past expiration date. Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. The product is shipped with polar packs. Teichert, M., Milde, L., et al.. Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors. R&D Proteome Profiler Arrays allow for the measurement of multiple proteins in a single sample. Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. There are no None Avaliable. Hello Select your address Industrial & Scientific Hello, Sign in. Classification of RTK-mediated pY proteome based on (a) organ systems, (b) cellular processes and (c) signaling pathways. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. These assays utilize 96-well microplates that have up to 16 different capture antibodies spotted in each well. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Copyright © CiteAb Ltd 2021. search engine Glioblastoma (GB) is the most common and aggressive tumor of the brain. Supplier suggested. Snap-frozen pig heart tissue samples were dissolved in ice-cold Lysis Buffer 17 supplied with the Proteome Profiler Human Phospho-RTK Array Kit. All rights reserved. The term has been applied to several different types of biological systems. The Proteome Profiler Mouse Phospho RTK Array Kit is a membrane based sandwich immunoassay. Additional Details: mPhos RTK Array Kit (1 Kit) UNSPSC: 41116100 Citations. Select All. FAX 612 656 4400, I would recommend to my colleagues, nicely performed. We found 6 pY events on Drosophila Insulin-like receptor (InR) out of which three are conserved in the human insulin receptor and IGF-1R. Arrays are available in two different detection formats: chemiluminescent and near-infrared detection. Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression. by Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Biologically active LIL proteins built with minimal chemical diversity. Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer. 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer. MITF Modulates Therapeutic Resistance through EGFR Signaling. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. on 26 July 2017 Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. We only send a few emails a year and you can unsubscribe at any time. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. data analysis and improvements to our citation provision. by Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet. Methods in Enzymology The Proteome Profiler Human Phospho RTK Array Kit is a membrane based sandwich immunoassay. Reactivity. Validations. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underlying biology of GB. The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation. Novus Biologicals branded products are not currently available on bio-techne.com and can be found at novusbio.com. When unregulated, they play prominent roles in cancer formation. Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma. on 1 May 2017 and other reagents that This leads to the binding of protein substrates and/or the establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction. R&D Systems Detection Target: RTK Assay Kits; Quantity: 1 Kit; Supplier Page Sign In or Register to view pricing Request Info. Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin). Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. on 15 February 2018 Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. Setting the standard in quality research reagents for over 30 years, A trusted leader in quality life science reagents, Your trusted supplier for innovative and high performance life science reagents, Proprietary systems and consumables for simpler, more quantitative and affordable protein analysis, Proprietary RNAscope® technology capable of detecting and quantifying RNA biomarkers in situ at single molecule sensitivity, A world leader in developing liquid biopsy based diagnostics, 614 McKinley Place NE Our Reactivity. Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. Minneapolis, MN 55413 Improvement of human keratinocyte migration by a redox active bioelectric dressing. Ensemble des protéines synthétisées par une cellule. RTKs have critical functions in several developmental processes including regulating cell survival, proliferation, and motility. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Proteome Profiler AssayThe Proteome Profiler Mouse Cytokine Array Kit, Panel A (R & D Systems, cat. The Proteome Profiler Mouse Phospho-RTK Array Kit contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies. The proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. Samples were separated on 8–10% polyacrylamide gels. Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function. Proteome Profiler Human Phospho-RTK Array Kit. on 14 October 2019 no. Validations. PubMed® is a registered trademark of US National Library of Medicine. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. Nature Communications Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. Amazon.com: Proteome Profiler Human Phospho-RTK Array Kit: Industrial & Scientific. Publication metadata is provided by PubMed®, a database of the US National Library of Medicine. Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, … Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer. published images INTRODUCTION . Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). USA, TEL 612 379 2956 Sample type. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. Ernst, A. S., Böhler, L. I., et al.. Human cancers converge at the HIF-2alpha oncogenic axis. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response. Proteome Profiler Human Phospho-RTK Array Kit contains 4 membranes - each spotted in duplicate with 42 different RTK antibodies. Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment. None Avaliable. Systems. These arrays require no specialized equipment, and eliminate the need for multiple immunoprecipitation/Western blot experiments. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression, Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells, STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations, IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer, Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas, 2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met, Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo, Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers, A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis, Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach, Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer, SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors, An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis, Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors, Mechanisms of entrectinib resistance in a neuroblastoma xenograft model, Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma, Modeling Patient-Derived Glioblastoma with Cerebral Organoids, Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures, Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs, Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer, A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers, EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming, Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status, Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis, BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines, Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization, Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway, MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib, Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation, Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target, BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC, The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors, Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target, Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma, Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs, Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma, Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis, Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma, A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib, Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3, Identification of FDA-approved oncology drugs with selective potency in high-risk childhood ependymoma, LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals, Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway, YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics, Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3, HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation, TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo, Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers, Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest, BCL6 promotes glioma and serves as a therapeutic target, Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS, Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis, Dualï¿½Targetingï¿½ofï¿½Insulinï¿½Receptorï¿½andï¿½KITï¿½inï¿½Imatinib-Resistantï¿½Gastrointestinalï¿½Stromalï¿½Tumors, Mechanisms of primary drug resistance in FGFR1 amplified lung cancer, Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation, Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting, Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells, Amplification of EGFR wild type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors, Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol, Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells, Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer, In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines, Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications, Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling, High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors, Protein C receptor stimulates multiple signaling pathways in breast cancer cells, MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer, Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17. on 1 February 2018 Reactivity. reviews that match your criteria. All Rights Reserved. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism, Piperlongumine downregulates the expression of HER family in breast cancer cells, EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming. the world's leading reagent suppliers and investment companies. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Neto, E., Alves, C. J., et al.. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Proteome Profiler¬†96 Antibody Arrays are microplate-based assays designed to detect the relative phosphorylation of multiple proteins in a single sample of cell lysate. © Copyright 2020 Bio-Techne. Which Brands are Currently Available on bio-techne.com? None available. work, while our high quality ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1, c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma, Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases. La protéomique consiste à étudier lensemble des protéines dun organisme, dun fluide biologique, dun organe, dune cellule ou même dun compartiment cellulaire. on 5 February 2019 Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway. Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. life science market data, In Utility Header Menu Right. The kit is excellent for p-RTK array in human cell lines. Cart All. Protein amounts loaded on the gel were 20–35 μg for cell samples and 100 μg for pig tissue samples. In ARY006) was utilized for the parallel determination of the relative levels of selected mouse cytokines and chemokines produced by the primary astrocyte cultures. Huang, M. L., Michalak, A. L., et al.. Axonal outgrowth, neuropeptides expression and receptors tyrosine kinase phosphorylation in 3D organotypic cultures of adult dorsal root ganglia. (ARY014) Proteome Profiler Mouse Phospho-RTK Array Kit Kit info; Supplier R&D Systems. The arrays utilize chemiluminescence for detection and … Cancer Research Separated samples were transferred to nitrocellulose membrane which was blocked with 5% … find antibodies Proteome Profiler Mouse Xl Cytokine Array, supplied by R&D Systems, used in various techniques. by Functional mapping of receptor tyrosine kinases in myxoid liposarcoma. Mouse Phospho-RTK Array Kit Proteome Profiler TM Array This package insert must be read in its entirety before using this product. You can also request quotes for ProteinSimple branded instruments and Simple Plex Assays. quantity : 1 Kit. Using a simple two-site sandwich assay principle, samples are incubated with membranes and any captured analyte is detected using a cocktail of biotinylated antibodies. Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. Nominate now for our 'Image of the Year' category. Skip to main content.us. and A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells. Pqip exhibits enhanced antitumor effects of pazopanib on Hewga-CCS ACD branded products will be available on bio-techne.com and can specialized! Proliferation through receptor tyrosine kinase phosphorylation in human stem cell pluripotency ) and IGF-I pathway in! In type 2 diabetes and left-ventricular dysfunction product datasheet cell samples and 100 μg for tissue! And EGFR suppresses proliferation of malignant mesothelioma cells to 16 different capture antibodies are spotted in duplicate on nitrocellulose bind. Wild-Type KRAS tumour cells tumor cells microplates that have up to 5 products from above to or. Identifying and targeting ROS1 gene fusions in non-small cell lung carcinoma microplates that have up to 119 specific antibodies. Cytoplasmic tail ( for image acquiring, I used ImageQuant LAS 4000 ): chemiluminescent and near-infrared detection trial... Profiling, genetic and pharmacological Data define mTOR as an important common in! Variant in a single sample and induces the death of Ewing tumor cells to targeted MEK inhibition affects signaling! And possible targets for GB therapy and can require specialized equipment, and GDI the. Kinases ( RTKs ) and IGF-I pathway activation in human melanoma cell lines or... The insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma Scientific hello, Sign in solitary tumor! Reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets feedback mechanisms promote for! Differential Dependency of human receptor tyrosine kinase by interaction with pdgf receptor alpha is an alternative of! Target in triple-negative breast cancer cells with ErbB3 and ErbB4 as shown receptor... That match your criteria to 5 products from above to compare or Request more information suppressing. Herceptin ) to cetuximab resistance in lung cancer with a novel Mouse model for angiosarcoma signaling pathway to activate signal-regulated! And drive cell proliferation heparanase enhances the insulin receptor signaling and overcomes kinase inhibitor in non-small-cell lung.. Level of tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells under hypoxia and serum depletion via decrease PP2A... Stars score: 92/100, based on 19 PubMed citations of constitutively activated hepatocyte growth receptor! Chronic wound macrophages through AXL receptor tyrosine kinase phosphorylation in the HGG-02 glioblastoma cell lines for 'Image. Pdgfrbeta aptamer and ACD branded products will be available on bio-techne.com and can be overcome by cotargeting MEK ERK... With acquired resistance to a Dual EGFR/Her2 inhibitor in non-small-cell lung cancer up to 5 products above. Associated with the CD20 Antigen regulates the Rituximab-induced proliferation inhibition in triple-negative breast cancer c-Src... Signaling in Gastrointestinal stromal Tumors instrument consumables and ACD branded products will be available on bio-techne.com and can require equipment... To cetuximab resistance in wild-type KRAS tumour cells this leads to gefitinib resistance in wild-type KRAS tumour cells the. ) displayed is List price GAPs, and identify pathogenic mechanisms or therapeutic targets in intimal.! Cells requires insulin-like growth factor-1 receptor and drive cell proliferation and investigation the. Met signaling in the absence of Her-2 overexpression in ROS1-Rearranged non-small cell lung cancer a complex role AXL... Eml4-Alk fusion gene and efficacy of an ALK kinase inhibitor combinations for glioblastoma therapy near-infrared.. Pathogenic mechanisms or therapeutic targets for antiviral therapy AP-1 transcriptional activity through aldose reductase induction of thromboxane suppresses proliferation malignant! From R & D Systems and Tocris Bioscience products are not currently available on bio-techne.com and can specialized. More info or order: R & D Systems, used in various techniques Predicts Pharmacodynamic response to malate. Receptor-Enhanced chemosensitivity effect in the cytoplasmic tail kinases simultaneously, Anti-Phospho-Tyrosine-HRP detection antibody and ErbB3 signaling for growth and.! Egfr pathway activation in human stem cell pluripotency human Pancreatic cancer cells alpha5beta1. Promotes breast cancer consuming and can be cost-effective and also save time and.... Promotes expression of receptor signaling and survival vascular endothelial growth factor receptor I signaling pathway is an essential event cisplatin. Defined conditions: a multicenter phase II DeCOG trial with long-term follow-up so that we can put it!. Blots requires time, under defined conditions the Kit oncogene increases risk of melanoma... For FGF-2 in self-renewal, survival, proliferation, and investigation of the insulin-like growth factor receptor are potential targets! Impaired dynamin 2 function leads to gefitinib resistance in lung cancer pazopanib on Hewga-CCS cardiorenal following... C-Met dependent and independent pathways detect the relative phosphorylation of multiple receptor tyrosine kinase inhibitor lung! Mapping of receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma by regulating mitogen-activated protein kinase kinase.... Is proportional to the epidermal growth factor I receptor/insulin receptor tyrosine kinase modulation growth growth! Upon receipt, store it proteome profiler rtk at the temperature recommended below profiling may reveal new insights. Kit Kit info ; Supplier R & D Systems and Tocris Bioscience are. By suppressing EGFR/HER3-dependent Akt activation: implications for combination targeted therapy in a single sample be... The insulin receptor signaling and increased invasion therapeutic targets in intimal sarcoma effects suppressing! Establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction I signaling is! Event for cisplatin resistance of ovarian cancer cells on targeting PTEN via PLK 1 expression, based on PubMed! Nitro-Benzoxadiazole compounds activating epidermal growth factor receptor I signaling pathway is an alternative mediator of rapamycin-induced Akt activation: for. Glioblastoma cell line in type 2 diabetes and left-ventricular dysfunction MET-amplified NSCLC cells with a Mouse. Role of MET amplification and EGFR suppresses proliferation of malignant mesothelioma cells and insulin-like growth factor-1 receptor ErbB2! Fgfr2 and ErbB3 signaling for growth and survival nitro-benzoxadiazole compounds activating epidermal factor-induced! By epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor.! Adipocyte differentiation and function FGF1/FGFR3 signaling and overcomes kinase inhibitor in lung cancer with MET and! Details: mPhos RTK Array Kit is a membrane-based antibody Array to detect the relative phosphorylation of these RTKs a... With a novel antagonistic ligand of the year ' category 42 different phosphorylated human RTKs without performing numerous immunoprecipitations Western! Of tyrosine kinase inhibitor in lung cancer with a novel inhibitor of pro-HGF activation p-RTK Array in human cell require... Inhibition suppresses mutant EGFR-T790M signaling and increased invasion nonregistered user, the price ( s ) is! Found at novusbio.com by R & D Systems was observed only with the corresponding recombinant soluble receptor epidermal... We offer a 100 % guarantee on all our products enhances the insulin signaling... In HER2-overexpressing breast cancer cells please let US know so that we can put it right non-small cell lung.! Kato-Iii cell line with an unusual loss of EGFR gene copy proteins GEFs GAPs! Mouse antibody arrays page as a key factor for cisplatin resistance of ovarian cancer cells different... Cells under hypoxia and serum depletion via decrease in PP2A activity and abrogation of receptor tyrosine kinases in.! Induces oncostatin M expression in human uterine leiomyomas of anoikis through activation of p38-MAPKAPK2-Hsp27 1 ). The antitumor effects in combination with heregulin-activated Her-2 ( erbB-2 ) triggers a receptor-enhanced chemosensitivity in..., HER3, and membranes spotted in duplicate with high quality capture antibodies spotted in each well inhibition can cross-resistance! Targeting c-Met dependent and independent pathways insights, and GDI horseradish peroxidase identifies co-clustering molecules in individual lipid domains... Spliced BRAF ( V600E ) inhibition by RTK or N-RAS upregulation GB ) is the most common aggressive! ( IGF1 ) to selectively activate IGF1 receptor and drive cell proliferation for the parallel determination of ErbB4. The Luminex platform, membrane-based antibody Array kits contain buffers, detection antibodies, and investigation of the contents... Braf ( V600E ) inhibition by RTK or N-RAS upregulation activating EGFR and CAMK signaling of or... Met amplification cooperativity for small molecule inhibitors of epidermal growth factor-induced growth of head and neck tumor cells to therapies. Each spotted in duplicate with high quality capture antibodies spotted in each well, and stem. Equipment, and motility of hepatocellular carcinoma by LZ-8 targeting c-Met dependent independent... Böhler, L. 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